MYD88mutation status does not impact overall survival in Waldenström macroglobulinemia
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چکیده
منابع مشابه
Population-based study on the impact of the familial form of Waldenström macroglobulinemia on overall survival.
Population-based study on the impact of the familial form of Waldenström macroglobulinemia on overall survival Waldenström macroglobulinemia (WM) is a chronic lymphoprolifer-ative disorder (LP) characterized by an immunoglobulin M monoclonal gammopathy in the presence of lymphoplasmacytic lymphoma (LPL) in the bone marrow. 1 We have previously shown in a large population-based study that first-...
متن کاملWaldenström macroglobulinemia.
Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma. A serum monoclonal IgM protein is required to establish this diagnosis. The clinical features patients develop include normochromic normocytic anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy and signs of hyperviscosity. The International Staging System for Waldenström macroglobulinemia divides patients prognostically ...
متن کاملExtramedullary Waldenström macroglobulinemia.
Disease assessment in Waldenstrom Macroglobulinemia (WM) is dependent on the percent involvement of B-cell neoplasm in the bone marrow and IgM paraprotein in the serum. A subset of patients also demonstrates extramedullary involvement, which is infrequently examined. The role of extramedullary involvement in the diagnosis and prognosis of WM is poorly understood. The purpose of this study is to...
متن کاملRisk of second cancers in Waldenström macroglobulinemia.
BACKGROUND An increased incidence of second cancers has been reported in lymphoproliferative disorders. PATIENTS AND METHODS We assessed the frequency, characteristics and predictive factors of second cancers in 230 patients with Waldenström macroglobulinemia (WM) and compared the incidence of second cancers in WM with that of an age- and sex-matched control population. RESULTS Twenty-two p...
متن کاملUpdate on therapeutic options in Waldenström macroglobulinemia.
Waldenström macroglobulinemia (WM) is a B-cell disorder characterized primarily by bone marrow infiltration with lymphoplasmacytic cells (LPCs), along with demonstration of an IgM monoclonal gammopathy in the blood. WM remains incurable, with 5-6 yr median overall survival for patients with symptomatic WM. The main therapeutic options include alkylating agents, nucleoside analogues, and rituxim...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2017
ISSN: 0361-8609
DOI: 10.1002/ajh.24955